Pilorute Cream is used to treat anal fissures and haemorrhoids (piles). It promotes healing, decreases the sensation of pain and lowers inflammation, irritation and discomfort. In some cases, this medicine may cause side effects such as burning sensation, irritation, itching and redness at the site of application. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.